Kindred Biosciences Unveils Results from Study of its Monoclonal Antibody for Atopic Dermatitis in Dogs
San Fransisco, Calif., Dec. 16, 2019 — Kindred Biosciences, Inc. (NASDAQ: KIN), a commercial-stage biopharmaceutical company focused on saving and improving the lives of pets, today unveiled positive results from its randomized, placebo-controlled laboratory pilot study of KIND-032, a fully caninized monoclonal antibody targeting interleukin-4 receptor (IL-4R), for the treatment of atopic dermatitis in dogs.
In the study, 14 laboratory dogs with clinical signs consistent with atopic dermatitis were dosed with placebo or with KIND-032 at two different doses. The CADESI scores were assessed by board-certified veterinary dermatologists who were blinded to treatment assignments. The study demonstrated that KindredBio’s antibody was well-tolerated. Although the study was a single-dose study designed primarily to assess safety and pharmacokinetics, evidence of positive efficacy and dose response was observed at Week 1, as measured by CADESI-04. A second pilot study to further assess efficacy and dosing is planned for 2020.
“The results exceeded our expectations for this small, single-dose study,” said KindredBio’s Chief Executive Officer, Richard Chin, M.D. “This is another in a string of positive results for our biologics candidates, and brings us closer to our goal of becoming a leader in canine dermatitis. We are particularly pleased with this program’s rapid progress, which is also surpassing our expectations.”
The IL-4 pathway is a key driver of the inflammation that underlies atopic dermatitis and several other allergic diseases. Unlike the company’s anti-IL-4/IL-13 SINK molecule, which binds to IL-4 and IL-13 circulating in blood, KIND-032 binds to the IL-4 receptor on the surface of immune cells. As a result of blockade of IL-4R, it prevents both IL-4 and IL-13 signaling pathways. The efficacy profiles, the subgroups of patients who respond to the biologics, and the ability to combine the biologics with other therapeutics may therefore differ between the two molecules.
Atopic dermatitis is the leading reason owners take their dog to the veterinarian, and the current market is over $700 million annually.
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The results stated in this press release have not been reviewed by the United States Department of Agriculture Center for Veterinary Biologics.
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